Factor V Leiden + Prothrombin G20210A
Both Factor V Leiden and Prothrombin G20210A variants detected.
You have DNA changes in both of the two most common inherited clotting variants.
Carrying both variants substantially raises the lifetime risk of venous thromboembolism compared with carrying either alone. Risk modifies clinical decisions around surgery, pregnancy, and contraception.
Having both variants substantially raises your lifetime risk of a dangerous blood clot — much more than having either one alone. It's worth flagging to clinicians around surgery, pregnancy, and birth control choices.
What this means
These two variants each individually modestly increase clotting risk. In combination, the risk is multiplicative rather than additive in many studies, particularly under triggering conditions like surgery, prolonged immobilisation, hormonal contraception, or pregnancy. This combination is a recognised consideration in surgical planning and reproductive decisions.
On their own, each of these DNA changes only modestly raises your chance of an unwanted blood clot. Together they tend to multiply rather than add — especially when something extra is going on, like surgery, a long period of not moving, hormonal birth control, or pregnancy. Doctors specifically take this combination into account when planning operations and discussing pregnancy or contraception.
Caveats
- Most carriers of both variants never experience a clotting event.
- Risk is strongly modified by surgery, immobilisation, hormonal therapy, smoking, and pregnancy.
- Anticoagulation is not routinely recommended for asymptomatic compound carriers — risk-benefit varies by circumstance.
- Genetic counselling is recommended before sharing this result with relatives.
References
- Emmerich et al. — Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism (Thrombosis and Haemostasis, 2001)
- Salomon et al. — Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism (Arteriosclerosis, Thrombosis, and Vascular Biology, 1999)