CYP2D6*10 — reduced enzyme activity (common in East Asians)
One copy of the CYP2D6*10 reduced-function variant detected.
You have one working copy and one less-active copy of the CYP2D6 gene.
Intermediate CYP2D6 activity. Affects the metabolism of many common drugs including codeine, tramadol, several antidepressants, and tamoxifen.
Your body processes a long list of common medicines a bit more slowly than average — including the painkillers codeine and tramadol, several antidepressants, and the breast-cancer drug tamoxifen.
What this means
CYP2D6 is one of the most variable drug-metabolising genes. *10 is the most common reduced-function allele in East Asian populations and contributes to the noticeable inter-ethnic differences in drug response for CYP2D6 substrates. Full CYP2D6 phenotyping requires looking at copy number and multiple SNPs; single-SNP inference from chip data is approximate.
CYP2D6 is one of the most variable drug-processing enzymes in your liver, and different versions of the gene make a meaningful difference in how some common medicines work. The *10 version produces an enzyme that works less efficiently than average. It's particularly common in East Asian populations, which is part of why people from different ancestries sometimes respond differently to the same drug at the same dose. Be aware that CYP2D6 is genetically complex — a single DNA reading like this one gives a useful hint but doesn't capture the full picture; a specialist test gives more detail if you ever need it.
Caveats
- CYP2D6 inference from a single SNP is incomplete; specialist testing gives the full picture.
- Most relevant if a CYP2D6 substrate drug is prescribed.
- The effect is "intermediate metabolizer" rather than complete loss of function.
Populations
- Common in East Asian populations (~40% allele frequency); also present elsewhere at lower frequencies