HFE H63D
One copy of HFE H63D detected.
You have one copy of the HFE H63D DNA change.
A mild variant in the same hemochromatosis gene as C282Y. On its own, one copy is essentially clinically silent.
This is a mild change in the same gene as C282Y. On its own, one copy makes no real difference to your health.
What this means
H63D is the second commonly tested HFE variant. It has a milder effect on the protein than C282Y. Its clinical relevance is greatest when paired with one C282Y allele (the "compound heterozygous" state), which carries a small risk of iron overload — much smaller than C282Y/C282Y but worth knowing if you also have unexplained fatigue, joint pain, or elevated ferritin.
H63D is the second of the two commonly tested DNA changes in the iron- regulation gene HFE. It has a milder effect on the protein than C282Y. It matters most when you also have one copy of C282Y — that pair carries a small risk of iron overload, much less than two copies of C282Y but still worth knowing about if you have unexplained fatigue, joint pain, or high ferritin on a blood test.
Caveats
- One copy of H63D is essentially incidental.
- Two H63D copies alone rarely produce clinically meaningful iron overload.
- The compound C282Y/H63D state carries a small added risk and is more clinically relevant when combined with metabolic factors.