LPA rs10455872 — elevated lipoprotein(a)
One copy of the LPA rs10455872 G allele detected.
You have one copy of a DNA change in the LPA gene linked to higher Lp(a) levels in your blood.
Strongly associated with higher circulating lipoprotein(a), a lipid particle linked to increased risk of coronary artery disease and aortic stenosis. Effect size is meaningful even in one copy.
This is strongly linked to higher levels of a fatty blood particle called Lp(a), which raises the lifetime risk of heart artery disease and stiffening of the aortic valve. Even one copy makes a meaningful difference.
What this means
Lipoprotein(a) — pronounced "L-P-little-a" — is an LDL-like particle whose blood level is set almost entirely by genetics. Elevated Lp(a) is one of the most under-recognised inherited cardiovascular risk factors. rs10455872 is one of the strongest common SNPs predicting high Lp(a), particularly in European-descent populations. Unlike cholesterol, Lp(a) doesn't respond meaningfully to statins or lifestyle changes; treatment options are limited, though several Lp(a)-targeted drugs are in late-stage trials.
Lipoprotein(a) — pronounced "L-P-little-a" — is a particle in your blood, similar to LDL cholesterol, whose level is set almost entirely by your DNA. High Lp(a) is one of the most overlooked inherited risk factors for heart disease. This DNA change is one of the strongest common markers for high Lp(a), especially in people of European ancestry. Unlike regular cholesterol, Lp(a) doesn't really respond to statins or to diet and exercise. Treatment options are limited for now, though several drugs that target Lp(a) directly are in late-stage trials.
Caveats
- This SNP is a strong predictor in European populations; effect size differs in others.
- A clinical Lp(a) blood test is more informative than a genetic surrogate — request one if this is concerning.
- Most people with elevated Lp(a) never have a cardiovascular event, but it shifts overall risk.