LPA rs3798220 — elevated lipoprotein(a)
One copy of the LPA rs3798220 C allele detected.
You have one copy of a second LPA DNA change linked to higher Lp(a) levels.
A second well-replicated variant predicting elevated lipoprotein(a). One copy is enough to push Lp(a) above the typical reference range.
This is the second well-studied marker for higher Lp(a). Even one copy is usually enough to push your blood Lp(a) above the typical range.
What this means
Together with rs10455872, this SNP is one of the two strongest common predictors of elevated lipoprotein(a). It tags a particular set of LPA "kringle" repeat copies that produce small, particularly atherogenic Lp(a) particles. The two SNPs identify slightly different subsets of high-Lp(a) individuals, so the picture is most complete when both are considered together.
This is one of the two strongest common DNA markers for high lipoprotein(a), or Lp(a). It points to a particular version of the LPA gene that produces small, particularly artery-damaging Lp(a) particles. It and the other strong marker (rs10455872) each pick up slightly different groups of people with high Lp(a), so checking both gives the most complete picture.
Caveats
- Most relevant in European-descent populations; effect differs elsewhere.
- A direct Lp(a) blood test is more useful than a genetic surrogate.
- High Lp(a) is a risk factor among many — not a verdict.