MTHFR A1298C
One copy of the MTHFR A1298C variant detected.
You have one copy of the MTHFR A1298C DNA change.
A common variant in the same gene as C677T. On its own it produces a smaller reduction in enzyme activity and is not considered clinically actionable.
This is a common DNA change in the same gene as C677T. On its own it only slightly lowers an enzyme's activity and isn't something doctors recommend acting on.
What this means
A1298C is the second commonly tested MTHFR variant, often reported alongside C677T. It has a smaller effect on enzyme activity. Most of the clinical literature on MTHFR risk concerns C677T or the compound heterozygous C677T/A1298C state. Like C677T, mainstream genetics organisations recommend against routine testing.
A1298C is the second of the two commonly tested MTHFR DNA changes, often reported alongside the better-known C677T. It has a smaller effect on the enzyme. Most of the medical research on MTHFR focuses on C677T or on the combination of one A1298C with one C677T. Like with C677T, the main medical genetics organisations specifically recommend against testing for this routinely.
Caveats
- On its own A1298C is essentially clinically silent.
- The compound C677T/A1298C heterozygous state has been studied with mixed results.
- As with C677T, the marketing-driven narrative around "MTHFR mutations" is much louder than the evidence supports.