TNFAIP3 — modest autoimmunity risk
One copy of the TNFAIP3 autoimmunity risk allele detected.
You have one copy of a DNA change near the TNFAIP3 gene that slightly nudges several autoimmune risks up.
Associated with a small lifetime increase in risk for several autoimmune conditions including rheumatoid arthritis and lupus. Effect on any single condition is small.
Your lifetime odds are slightly higher for several autoimmune conditions, including rheumatoid arthritis and lupus. The bump for any single condition is small.
What this means
TNFAIP3 (also called A20) is a negative regulator of NF-κB signalling. Common variants near this gene contribute small increments to the risk of several autoimmune diseases. Like PTPN22 it is a "broad-spectrum" immune set-point variant rather than a disease-specific one.
TNFAIP3 (sometimes called A20) makes a protein that acts as a brake on inflammatory signalling inside your cells. Common DNA changes near this gene each add a small amount to the risk of several autoimmune diseases. Like the PTPN22 R620W variant, this is a "broad-spectrum" change that nudges your immune system's overall set-point rather than driving any one specific disease.
Caveats
- Effect on any single condition is small.
- Most carriers never develop autoimmune disease.
- Not used in clinical risk stratification.